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Science behind FODZYME

SHIME® experiment

a scientifically validated model of a human gut.

Enzymatic digestion

in simulated gastric conditions with FODZYME

Decrease of Gas

production in model GI tract with FODZYME

SCFA Production

Short Chain Fatty Acids production is lower but preserved

Powder vs capsules

Specific mode of administration for optiomal integration

We tested FODZYME in SHIME®, a multi-compartment scientifically validated model of the complete human gut, to study the efficacy of FODZYME’s fructan hydrolase in fructan degradation.

A dose of FODZYME was added together with 3g of inulin (a common source of fructan) to see how effectively FODZYME’s fructan hydrolase breaks down fructan.

Findings indicated rapid breakdown of fructan to fructose in gastric conditions with ~90% of the inulin mass converted to fructose within 30 minutes thus demonstrating resilience to both gastric pH and protease activity.

Further intestinal modeling demonstrated a significant portion of the released fructose was absorbed during simulated small intestinal transit (70%), with a corresponding decrease in microbial gas production.

SCFA production was reduced but not depleted, suggesting FODZYME’s enzymatic approach may be more favorable to colonic health than avoiding FODMAPs altogether [4].

It is critical for the enzyme to distribute in the ingested food bolus as quickly as possible to take advantage of the optimal pH range for enzymatic activity immediately following a meal. Later on, gastric pepsin becomes considerably more active and other proteases threaten enzyme stability.

FODZYME’s powder formulation maximizes homogenization of enzymes and food and thus the availability of enzymes to their substrates at the post-prandial gastric pH most favorable to microbial carbohyrases.

Science behind FODZYME

SHIME® experiment

a scientifically validated model of a human gut.

We tested FODZYME in SHIME®, a multi-compartment scientifically validated model of the complete human gut, to study the efficacy of FODZYME’s fructan hydrolase in fructan degradation.

Enzymatic digestion

in simulated gastric conditions with FODZYME

A dose of FODZYME was added together with 3g of inulin (a common source of fructan) to see how effectively FODZYME’s fructan hydrolase breaks down fructan.

Findings indicated rapid breakdown of fructan to fructose in gastric conditions with ~90% of the inulin mass converted to fructose within 30 minutes thus demonstrating resilience to both gastric pH and protease activity.

Decrease of Gas

production in model GI tract with FODZYME

Further intestinal modeling demonstrated a significant portion of the released fructose was absorbed during simulated small intestinal transit (70%), with a corresponding decrease in microbial gas production.

SCFA Production

Short Chain Fatty Acids production is lower but preserved

SCFA production was reduced but not depleted, suggesting FODZYME’s enzymatic approach may be more favorable to colonic health than avoiding FODMAPs altogether [4].

Powder vs capsules

Specific mode of administration for optiomal integration

It is critical for the enzyme to distribute in the ingested food bolus as quickly as possible to take advantage of the optimal pH range for enzymatic activity immediately following a meal. Later on, gastric pepsin becomes considerably more active and other proteases threaten enzyme stability.

FODZYME’s powder formulation maximizes homogenization of enzymes and food and thus the availability of enzymes to their substrates at the post-prandial gastric pH most favorable to microbial carbohyrases.

The FODZYME factor

FODZYME works as you digest your meal by breaking down the FODMAPs, effectively eliminating them in your gut.

#1 If you’re new to the low fodmap diet

#2 if you’re familiar with the low fodmap diet

#3 best practices

#4 if you’re familiar with the low fodmap diet

1

#1 If you’re new to the low fodmap diet

2

#2 if you’re familiar with the low fodmap diet

3

#3 best practices

4

#4 if you’re familiar with the low fodmap diet

The FODZYME factor

FODZYME works as you digest your meal by breaking down the FODMAPs, effectively eliminating them in your gut.

#1 If you’re new to the low fodmap diet

#2 if you’re familiar with the low fodmap diet

#3 best practices

#4 if you’re familiar with the low fodmap diet

Better digestion with a sprinkle of magic

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We create the best enzymes

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We create the best enzymes

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Better digestion with a sprinkle of magic

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Proin consectetur justo quis euismod vehicula. Quisque diam dui, imperdiet et hendrerit in, accumsan tempus erat.

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